Natural history of hepatic metastases from colorectal cancer-pathobiological pathways with clinical significance
Konstantinos A Paschos;Ali W Majeed;Nigel C Bird;Liver Research Group;Department of Oncology;School of Medicine;Royal Hallamshire Hospital;The University of Sheffield;Department of Surgery;General Hospital of Drama;

..............page:3719-3737

Colorectal cancer and immunity:what we know and perspectives
Simon Pernot;Magali Terme;Thibault Voron;Orianne Colussi;Elie Marcheteau;Eric Tartour;Julien Taieb;Service d’Hépatogastro-entérologie et d’oncologie digestive;H?pital Européen Georges-Pompidou;Université Paris Descartes;Sorbonne Paris Cité;INSERM U970;Paris Cardiovascular Research Center;Université Paris-Descartes;Service d’Immunologie biologique;H?pital Européen Georges-Pompidou;Université Paris Descartes;

..............page:3738-3750

Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer:The role of inflammation
Chun Seng Lee;Elizabeth J Ryan;Glen A Doherty;Centre for Colorectal Disease;St. Vincent’s University Hospital;School of Medicine and Medical Sciences;University College Dublin;

..............page:3751-3761

Personalized surgical management of colorectal cancer in elderly population
Giampaolo Ugolini;Federico Ghignone;Davide Zattoni;Giacomo Veronese;Isacco Montroni;Department of Medical and Surgical Sciences;University of Bologna;Policlinico S. Orsola-Malpighi;

..............page:3762-3777

Inhibition of host immune response in colorectal cancer:Human leukocyte antigen-G and beyond
Marica Garziera;Giuseppe Toffoli;Experimental and Clinical Pharmacology Unit;CRO Aviano National Cancer Institute;

..............page:3778-3794

Role of preoperative CT colonography in patients with colorectal cancer
Lapo Sali;Massimo Falchini;Antonio Taddei;Mario Mascalchi;Department of Experimental and Clinical Biomedical Sciences;University of Florence;Department of Surgery and Translational Medicine;University of Florence;

..............page:3795-3803

Proteomics for discovery of candidate colorectal cancer biomarkers
Paula lvarez-Chaver;Olalla Otero-Estévez;María Páez de la Cadena;Francisco J Rodríguez-Berrocal;Vicenta S Martínez-Zorzano;Unidad de Proteómica;Servicio de Determinación Estructural;Proteómica y Genómica;Centro de Apoyo Científico y Tecnológico a la Investigación;Universidad de Vigo;Campus As Lagoas-Marcosende;área de Bioquímica y Biología Molecular;Departamento de Bioquímica;Genética e Inmunología;Facultad de Biología;Universidad de Vigo;Campus As Lagoas-Marcosende;

..............page:3804-3824

Colorectal cancer screening:20 years of development and recent progress
Miroslav Zavoral;Stepan Suchanek;Ondrej Majek;Premysl Fric;Petra Minarikova;Marek Minarik;Bohumil Seifert;Ladislav Dusek;Department of Medicine;1st Faculty of Medicine;Military University Hospital;Charles University;Institute of Biostatistics and Analyses;Masaryk University;Genomac Research Institute;Centre for Applied Genomics of Solid Tumors;Institute of General Medicine;1st Faculty of Medicine;Charles University;

..............page:3825-3834

Chemopreventive drugs:Mechanisms via inhibition of cancer stem cells in colorectal cancer
Tae Il Kim;Department of Internal Medicine and Institute of Gastroenterology;Yonsei University College of Medicine;

..............page:3835-3846

Current and future molecular diagnostics in colorectal cancer and colorectal adenoma
Andy Hin-Fung Tsang;Ka-Ho Cheng;Apple Siu-Ping Wong;Simon Siu-Man Ng;Brigette Buig-Yue Ma;Charles Ming-Lok Chan;Nancy Bo-Yin Tsui;Lawrence Wing-Chi Chan;Benjamin Yat-Ming Yung;Sze-Chuen Cesar Wong;Department of Health Technology and Informatics;Faculty of Health and Social Sciences;Hong Kong Polytechnic University;Department of Surgery;Prince of Wales Hospital;State Key Laboratory in Oncology in South China;Sir Y K Pao Centre for Cancer;Department of Clinical Oncology;Hong Kong Cancer Institute and Prince of Wales Hospital;The Chinese University of Hong Kong;

..............page:3847-3857

Predictive and prognostic biomarkers with therapeutic targets in advanced colorectal cancer
Hui-Yan Luo;Rui-Hua Xu;Department of Medical Oncology;Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China;Collaborative Innovation Center for Cancer Medicine;

..............page:3858-3874

Gastric cancer in Africa:Current management and outcomes
Akwi W Asombang;Rubayat Rahman;Jamal A Ibdah;Division of Gastroenterology and Hepatology;University of Missouri;Columbia;

..............page:3875-3879

Current role of minimally invasive approaches in the treatment of early gastric cancer
Abraham El-Sedfy;Savtaj S Brar;Natalie G Coburn;Department of Surgery;Saint Barnabas Medical Center;Livingston;Division of Surgical Oncology;Odette Cancer Centre;Sunnybrook Health Sciences Centre;

..............page:3880-3888

Extent of lymphadenectomy and perioperative therapies:two open issues in gastric cancer
Andrea Giuliani;Michelangelo Miccini;Luigi Basso;Department of Surgery "Pietro Valdoni";"Sapienza" University of Rome;Medical School;

..............page:3889-3904

Treatment options in patients with metastatic gastric cancer:Current status and future perspectives
Ahmet Bilici;Department of Medical Oncology;Medical Faculty;Istanbul Medipol University;

..............page:3905-3915

DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus
Keisuke Matsusaka;Sayaka Funata;Masashi Fukayama;Atsushi Kaneda;Department of Molecular Oncology;Graduate School of Medicine;Chiba University;Department of Pathology;Graduate School of Medicine;The University of Tokyo;CREST;Japan Science and Technology Agency;

..............page:3916-3926

An updated review of gastric cancer in the next-generation sequencing era:Insights from bench to bedside and vice versa
Hiroyuki Yamamoto;Yoshiyuki Watanabe;Tadateru Maehata;Ryo Morita;Yoshihito Yoshida;Ritsuko Oikawa;Shinya Ishigooka;Shun-ichiro Ozawa;Yasumasa Matsuo;Kosuke Hosoya;Masaki Yamashita;Hiroaki Taniguchi;Katsuhiko Nosho;Hiromu Suzuki;Hiroshi Yasuda;Yasuhisa Shinomura;Fumio Itoh;Division of Gastroenterology and Hepatology;Department of Internal Medicine;St. Marianna University School of Medicine;Division of Cancer Cell Research;Institute of Medical Science;University of Tokyo;Department of Gastroenterology;Rheumatology and Clinical Immunology;Sapporo Medical University School of Medicine;Department of Molecular Biology;Sapporo Medical University School of Medicine;

..............page:3927-3937

Endoscopic submucosal dissection for undifferentiated-type early gastric cancer:Do we have enough data to support this?
Choong Nam Shim;Sang Kil Lee;Department of Internal Medicine;Institute of Gastroenterology;Yonsei University College of Medicine;

..............page:3938-3949

Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression
Hsin-Chen Lee;Kuo-Hung Huang;Tien-Shun Yeh;Chin-Wen Chi;Institute of Pharmacology;School of Medicine;National Yang-Ming University;Division of General Surgery;Department of Surgery;Taipei Veterans General Hospital;Institute of Clinical Medicine;School of Medicine;National Yang-Ming University;Department of Anatomy and Cell Biology;School of Medicine;National Yang-Ming University;Department of Medical Research and Education;Taipei Veterans General Hospital;

..............page:3950-3959

New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer
Lin-Hai Yan;Wei-Yuan Wei;Yu-Bo Xie;Qiang Xiao;Department of Surgery;The First Affiliated Hospital of Guangxi Medical University;Department of Anesthesiology;The First Affiliated Hospital of Guangxi Medical University;

..............page:3960-3966

Clinical significance of lymph node metastasis in gastric cancer
Jing-Yu Deng;Han Liang;Gastric Oncology Division;Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cancer Center;National Clinical Center of Cancer;

..............page:3967-3975

Post-infectious irritable bowel syndrome:Mechanistic insights into chronic disturbances following enteric infection
Jennifer K Beatty;Amol Bhargava;Andre G Buret;Department of Biological Sciences;University of Calgary;

..............page:3976-3985

HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation
Bjarte Fosby;Sigrid Nss;Johannes R Hov;James Traherne;Kirsten M Boberg;John Trowsdale;Aksel Foss;Pl-Dag Line;Andre Franke;Espen Melum;Helge Scott;Tom H Karlsen;Norwegian PSC Research Center;Division of Cancer;Surgery and Transplantation;Oslo University Hospital;Institute of Clinical Medicine;Faculty of Medicine;University of Oslo;KG Jebsen Inflammation Research Centre;Research Institute of Internal Medicine;Oslo University Hospital;Department of Transplantation Medicine;Division of Cancer;Surgery and Transplantation;Oslo University Hospital;Division of Immunology;Department of Pathology;University of Cambridge and Cambridge Institute for Medical Research;University of Cambridge;Institute of Clinical Molecular Biology;Christian-Albrechts-University;Department of Pathology;Divisoin of Diagnostics and Intervention;Institute of Pathology;Oslo University Hospital;

..............page:3986-4000

Epithelial membrane protein 1 negatively regulates cell growth and metastasis in colorectal carcinoma
Guo-Gui Sun;Ya-Di Wang;Da-Wei Cui;Yun-Jie Cheng;Wan-Ning Hu;Department of Chemoradiotherapy;Tangshan People’s Hospital;Department of Radiotherapy;the Military General Hospital of Beijing PLA;Department of Urology;Tangshan Workers Hospital;Department of Radiotherapy;The Fourth Hospital of Hebei Medical University;

..............page:4001-4010

Immunohistochemical assessment of NY-ESO-1 expression in esophageal adenocarcinoma resection specimens
Stephen J Hayes;Keng Ngee Hng;Peter Clark;Fiona Thistlethwaite;Robert E Hawkins;Yeng Ang;Department of Histopathology;Salford Royal NHS Foundation Trust;Faculty of Medical and Human Sciences;University of Manchester;Department of Gastroenterology;Salford Royal NHS Foundation Trust;Department of Medical Oncology;The Christie NHS Foundation Trust;Department of Medical Oncology;Paterson Institute of Cancer Research;University of Manchester;

..............page:4011-4016

Positive predictors for gastroesophageal reflux disease and the therapeutic response to proton-pump inhibitors
Valentin Becker;Stefan Grotz;Christoph Schlag;Simon Nennstiel;Analena Beitz;Bernhard Haller;Roland M Schmid;Alexander Meining;Monther Bajbouj;Ⅱ. Medizinische Klinik und Poliklinik;Technische Universit?t München;Institut für Medizinische Statistik und Epidemiologie;Technische Universit?t München;

..............page:4017-4024

Non-small-bowel abnormalities identified during small bowel capsule endoscopy
Reinier A Hoedemaker;Jessie Westerhof;Rinse K Weersma;Jan J Koornstra;Department of Gastroenterology and Hepatology;University Medical Centre Groningen;University of Groningen;

..............page:4025-4029

Combined laparoscopic spleen-preserving distal pancreatectomy and islet autotransplantation for benign pancreatic neoplasm
Gianpaolo Balzano;Michele Carvello;Lorenzo Piemonti;Rita Nano;Riccardo Ariotti;Alessia Mercalli;Raffaella Melzi;Paola Maffi;Marco Braga;Carlo Staudacher;Department of Surgery;San Raffaele Research Institute;Division of Immunology;Transplantation;and Infectious Diseases-Diabetes Research Institute;Islet Processing Activity;San Raffaele Research Institute;

..............page:4030-4036

Seasonal variations of acute appendicitis and nonspecific abdominal pain in Finland
Imre Ilves;Anne Fagerstrm;Karl-Heinz Herzig;Petri Juvonen;Pekka Miettinen;Hannu Paajanen;Department of Surgery;Kuopio University Hospital;Institute of Biomedicine;Division of Physiology and Biocenter of Oulu;University of Oulu;Department of Psychiatry;Kuopio University Hospital;

..............page:4037-4042

Acute right lower abdominal pain in women of reproductive age:Clinical clues
Sinan Hatipoglu;Filiz Hatipoglu;Ruslan Abdullayev;Department of General Surgery Unit;School of Medicine;Adiyaman University;Department of Obstetrics and Gynecology Unit;School of Medicine;Adiyaman University;Department of Anesthesiology and Reanimation Unit;School of Medicine;Adiyaman University;

..............page:4043-4049

Clinical study using novel endoscopic system for measuring size of gastrointestinal lesion
Kiyoshi Oka;Takeshi Seki;Tomohiro Akatsu;Takao Wakabayashi;Kazuo Inui;Junji Yoshino;OK Fiber Technology Co.;Ltd.;Graduate School of engineering and Resource Science;Akita University;A-tech Co. Ltd.;Department of Internal Medicine;Banbuntane Hotokukai Hospital;Fujita Health University;

..............page:4050-4058

Single hepatocellular carcinoma ≤ 3 cm in left lateral segment: Liver resection or radiofrequency ablation?
Jong Man Kim;Tae Wook Kang;Choon Hyuck David Kwon;Jae-Won Joh;Justin Sangwook Ko;Jae Berm Park;Hyunchul Rhim;Joon Hyeok Lee;Sung Joo Kim;Seung Woon Paik;Department of Surgery;Samsung Medical Center;Sungkyunkwan University School of Medicine;Department of Radiology and Center for Imaging Science;Samsung Medical Center;Sungkyunkwan University School of Medicine;Department of Anesthesiology and Pain Medicine;Samsung Medical Center;Sungkyunkwan University School of Medicine;Division of Gastroenterology;Department of Medicine;Samsung Medical Center;Sungkyunkwan University School of Medicine;

..............page:4059-4065

YouTube as a source of patient information on gallstone disease
Jun Suh Lee;Ho Seok Seo;Tae Ho Hong;Department of Surgery;Armed Forces Capital Hospital;Department of Surgery;Seoul St. Mary’s Hospital;College of Medicine;The Catholic University of Korea;

..............page:4066-4070

Efficacy and tolerability of low-dose interferon-α in hemodialysis patients with chronic hepatitis C virus infection
Kai-Li Wang;Han-Qian Xing;Hong Zhao;Jun-Wei Liu;Deng-Lian Gao;Xue-Hua Zhang;Hong-Yu Yao;Li Yan;Jun Zhao;Department of Blood Purification;302 Hospital of the People’s Liberation Army;

..............page:4071-4075

Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma
Xiao-Qing Yang;Yun-Fei Xu;Sen Guo;Yi Liu;Shang-Lei Ning;Xiao-Fei Lu;Hui Yang;Yu-Xin Chen;Department of Hepatobiliary Surgery;Qilu Hospital of Shandong University;Department of Pathology;Shandong University;Department of Gastrointestinal Surgery;Central Hospital of Shandong University;

..............page:4076-4084

Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer
Yun-Feng Wang;Fei-Ling Feng;Xu-Hong Zhao;Zhen-Xiong Ye;He-Ping Zeng;Zhen Li;Xiao-Qing Jiang;Zhi-Hai Peng;Department of Hepatobiliary Surgery;Qianfoshan Hospital;Shandong University;Department of General Surgery;Yangpu Hospital;Tongji University School of Medicine;The First Department of Biliary Surgery;Eastern Hepatobiliary Surgery Hospital of the Second Military Medical University;Central Experiment Laboratory;Yangpu Hospital;Tongji University School of Medicine;

..............page:4085-4092

Effect of precut sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis:A systematic review and meta-analysis
Abhishek Choudhary;Jessica Winn;Sameer Siddique;Murtaza Arif;Zainab Arif;Ghassan M Hammoud;Srinivas R Puli;Jamal A Ibdah;Matthew L Bechtold;Division of Gastroenterology;Department of Internal Medicine;University of Missouri-Columbia;Division of Gastroenterology and Hepatology;University of Illinois;Peoria Campus;OSF Saint Francis Medical Center;Peoria;

..............page:4093-4101

Simultaneous liver mucinous cystic and intraductal papillary mucinous neoplasms of the bile duct:A case report
Agnieszka Budzynska;Marek Hartleb;Ewa Nowakowska-Dulawa;Robert Krol;Piotr Remiszewski;Michal Mazurkiewicz;Department of Gastroenterology and Hepatology;Medical University of Silesia;Department of General;Vascular and Transplant Surgery;Medical University of Silesia;Department of General;Transplant and Liver Surgery;Medical University of Warsaw;Department of Pathological Anatomy;Medical University of Warsaw;

..............page:4102-4105

Primary rectal squamous cell carcinoma treated with surgery and radiotherapy
Jun-Feng Wang;Zhen-Xing Wang;Xiao-Xiao Xu;Cui Wang;Jian-Zhong Liu;Department of Colorectal Cancer;Tianjin Medical University Cancer Institute and Hospital;Tianjin Key Laboratory of Cancer Prevention and Therapy;National Clinical Research Center of Cancer;Department of Gastrointestinal Medical Oncology;Tianjin Medical University Cancer Institute and Hospital;Tianjin Key Laboratory of Cancer Prevention and Therapy;National Clinical Research Center of Cancer;Department of Hematology;Tianjin Medical University Cancer Institute and Hospital;Tianjin Key Laboratory of Cancer Prevention and Therapy;National Clinical Research Center of Cancer;

..............page:4106-4109

Prolonged small vessel vasculitis with colon mucosal inflammation as first manifestations of Behet’s disease
Xiao-Ning Yang;Zhen-Shi Ye;Yan-Yun Fan;Yi-Qun Hu;Department of Gastroenterology;Zhongshan Hospital Xiamen University;

..............page:4110-4114

INSTRUCTIONS TO AUTHORS

..............page:4115-4120