Synthesis and biological evaluation of piperazine derivatives on dipeptidyl peptidase-4
Xiangguo Meng; Zhengyan Cai; Wei Zhang; Weicheng Zhou * State Key Laboratory of New Drug & Pharmaceutical Process; Shanghai Key Lab of Anti-Infectives; Shanghai Institute of Pharmaceutical Industry; State Institute of Pharmaceutical Industry; Shanghai 200437; China

..............page:167-172

Expression, purification and activity assay of recombinant human thymidylate synthase
Chao Li; Ying Guo; Chao Tian; Shouxin Zhou; Rufeng Yan; Zhili Zhang; Xiaowei Wang; Junyi Liu * Department of Chemical Biology; School of Pharmaceutical Science; Peking University Health Science Center; Beijing 100191; China

..............page:173-176

Bioequivalence and safety study of letrozole tablet in healthy Chinese postmenopausal women volunteers
Yi Liu 1 ; Yifan Zhang 2 ; Qian Wang 1 ; Wei Yang 1 ; Xiaoyan Chen 2 ; Shan Jing 1 ; Libo Zhao 1 ; Chunyan Zhang 1 ; Lihui Wei 3 ; Xiaoping Li 3 ; Wanyu Feng 1 ; Dafang Zhong 2* ; Yi Fang 1* 1. Department of Pharmacy; Peking University People’s Hospital; Beijing 100044; China 2. Shanghai Institute of Materia Medica; Chinese Academy of Sciences; Shanghai 201203; China 3. Department of Gynecology and Obstetrics; Peking University People’s Hospital; Beijing 100044; China

..............page:190-196

Design, synthesis and evaluation of the cytotoxicity of a N-mustard and paclitaxel conjugate prodrug
Junchao Shao 1 ; Haixia Lin 1* ; Yongmei Cui 1 ; Shaoman Yin 2 ; Erwin G Van Meir 2 ; Jiachen Huang 1 1. Department of Chemistry; School of Science; Shanghai University; Shanghai 200444; China 2. Laboratory of Molecular Neuro-Oncology; Departments of Neurosurgery; Hematology and Medical Oncology; and Emory Winship Cancer Institute; Emory University School of Medicine; Atlanta; Georgia 30322; USA

..............page:137-143

Synthesis of 2-deoxy-2-chloro-1-amino sugars and evaluation of their cytotoxicity against cancer cells
Ming Zhong 1;2 ; Xikai Cui 2 ; Xiangbao Meng 2* ; Zhongjun Li 2* 1. Department of Pharmaceutical Sciences; Medical College of Shaoguan University; Shaoguan 512026; China 2. State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology; School of Pharmaceutical Sciences; Peking University Health Science Center; Beijing 100191; China

..............page:144-147

Three-dimensional common-feature hypotheses for Toll-like receptor 7 agonists
Shiguang Qi 1 ; Hui Yu 1 ; Hongwei Jin 2 ; Zhanli Wang 3* 1. The Second Affiliated Hospital; Baotou Medical College; Baotou 014030; China 2. State Key Laboratory of Natural and Biomimetic Drugs; Peking University Health Science Center; Beijing 100191; China 3. The First Affiliated Hospital; Baotou Medical College; Baotou 014010; China

..............page:148-153

Wbselen and gemcitabine synergistically inhibited the viability of JF305 and MiaPaCa-2 human pancreatic cancer cells
Yi Hui; Weiwei Ma; Kun Xiong; Huihui Zeng * State Key Laboratory of Natural and Biomimetic Drugs; Peking University Health Science Center; Beijing 100191; China

..............page:177-183

A new ent-pimarane diterpenoid from Siegesbeckia pubescens
Kehui Xie 1 ; Jianbin Wang 2 ;Rong Yang 1 ; Qiong Wu 1 ; Xiaoxue Pi 1 ; Hongzheng Fu 1* 1. State Key Laboratory of Natural and Biomimetic Drugs; School of Pharmaceutical Science; Peking University Health Science Center; Beijing 100191; China 2. Department of Pharmaceutics; School of Medical Academy; Yangzhou University; Yangzhou 225009; China

..............page:197-200

Realgar induces differentiation through ROS-dependent mitochondrial pathway in HL-60 cells
Lijia Yuan; Cong Wang; Wei Liu; Wenlong Liu; Baodi Gou * ; Tianlan Zhang * Department of Chemical Biology; School of Pharmaceutical Sciences; Peking University Health Science Center; Beijing 100191; China

..............page:184-189

Synthesis of (1E)-phenyl-2-(3’,4’-dihydroxyphenyl)ethenesulfonates as potent neuroprotective agents and evaluation of their activities
Zhutuo Chen; Xianling Ning; Junyi Liu * Department of Chemical Biology; School of Pharmaceutical Sciences; Peking University Health Science Center; Beijing 100191; China

..............page:161-166

Docking and 3D-QSAR studies of N-benzyl isatin oximes as JNK3 inhibitors
Yue Zhou; Na Zhang * ; Rugang Zhong College of Life Science and Bioengineering; Beijing University of Technology; Beijing 100124; China

..............page:154-160

Two new furostanol glycosides fromAsparagus cochinchinensis(Lour.) Merr.
Rui Jian 1 ; Jun Li 2 ; Kewu Zeng 1 ; Ning Li 1 ; Yong Jiang 1 ; Pengfei Tu 1* 1. State Key Laboratory of Natural and Biomimetic Drugs; School of Pharmaceutical Sciences; Peking University Health Science Center; Beijing 100191; China 2. Modern Research Center for Traditional Chinese Medicine; Beijing University of Chinese Medicine; Beijing 100029; China

..............page:201-204

Structure-activity relationship of cyclic ADP-ribose, an update
Andreas H. Guse * The Calcium Signalling Group; Department of Biochemistry and Signal Transduction; and Department of Biochemistry and Molecular Cell Biology; University Medical Center Hamburg-Eppendorf; Hamburg 20246; Germany

..............page:127-136