0513-4870
2014 Issue 6
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..............page:748
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Roles of adenosine receptors in Alzheimer’s disease
YAN Rong;HU Zeng-yao;ZHOU Wen-xia;WANG Qi;ZHANG Yong-xiang;Institute of Pharmacology and Toxicology;Academy of Military Medical Sciences;Institute of Clinical Pharmacology;Guangzhou University of Traditional Chinese Medicine;
YAN Rong;HU Zeng-yao;ZHOU Wen-xia;WANG Qi;ZHANG Yong-xiang;Institute of Pharmacology and Toxicology;Academy of Military Medical Sciences;Institute of Clinical Pharmacology;Guangzhou University of Traditional Chinese Medicine;
..............page:751-756
Full-scale setback and thinking in R&D of Alzheimer’s disease drug
YIN Ming;School of Pharmacy;Shanghai Jiao Tong University;
YIN Ming;School of Pharmacy;Shanghai Jiao Tong University;
..............page:757-763
Autophagy in ageing and ageing-related diseases
HUA Fang;YU Jiao-jiao;LI Ke;HU Zhuo-wei;State Key Laboratory of Bioactive Substance and Function of Natural Medicines;Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;Institute of Medicinal Biotechnology;Chinese Academy of Medical Sciences and Peking Union Medical College;
HUA Fang;YU Jiao-jiao;LI Ke;HU Zhuo-wei;State Key Laboratory of Bioactive Substance and Function of Natural Medicines;Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;Institute of Medicinal Biotechnology;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:764-773
Roles of microglia and immune receptors in Alzheimer’s disease
HE Xiao;SUN Bing-gui;Institute of Neuroscience;School of Medicine;Zhejiang University;Key Laboratory of Medical Neurobiology of Ministry of Health of China;
HE Xiao;SUN Bing-gui;Institute of Neuroscience;School of Medicine;Zhejiang University;Key Laboratory of Medical Neurobiology of Ministry of Health of China;
..............page:774-780
Progress in the studies on neuronal nitric oxide synthase inhibitors
ZHANG Chao-zai;DONG Lei;MU Feng-hui;YANG Xiao-hong;SUN Wei;School of Pharmacy;Jilin University;First Hospital;Jilin University;
ZHANG Chao-zai;DONG Lei;MU Feng-hui;YANG Xiao-hong;SUN Wei;School of Pharmacy;Jilin University;First Hospital;Jilin University;
..............page:781-788
Lead compound optimization strategy(4)——improving blood-brain barrier permeability through structural modification
HONG Yu;ZHOU Yu;WANG Jiang;LIU Hong;School of Pharmacy;China Pharmaceutical University;Key Laboratory of Receptor Research;Shanghai Institute of Materia Medica;Chinese Academy of Sciences;
HONG Yu;ZHOU Yu;WANG Jiang;LIU Hong;School of Pharmacy;China Pharmaceutical University;Key Laboratory of Receptor Research;Shanghai Institute of Materia Medica;Chinese Academy of Sciences;
..............page:789-799
Screening of 10 types of Chinese herbal compounds inhibiting Aβ and their possible related mechanism in vitro
ZHU Ran;HUANG Tian-xi;ZHAO Xue-mei;ZHANG Ji-min;LIANG Ping;Department of Pathology;Institute of Basic Medical Sciences;Chinese Academy of Medical Sciences &School of Basic Medicine;Peking Union Medical College;Research Center in Neurology;Harvard Medical School;
ZHU Ran;HUANG Tian-xi;ZHAO Xue-mei;ZHANG Ji-min;LIANG Ping;Department of Pathology;Institute of Basic Medical Sciences;Chinese Academy of Medical Sciences &School of Basic Medicine;Peking Union Medical College;Research Center in Neurology;Harvard Medical School;
..............page:800-806
Rosiglitazone improves learning and memory impairment of 3×Tg mice
SONG Jin-zhi;SUN Jie;JIN Duo-chen;DENG Yan-qiu;Basic Medical College;Tianjin Medical University;
SONG Jin-zhi;SUN Jie;JIN Duo-chen;DENG Yan-qiu;Basic Medical College;Tianjin Medical University;
..............page:807-812
Design, synthesis and evaluation of N-acyl-4-phenylthiazole-2-amines as acetylcholinesterase inhibitors
MA Zheng-yue;YANG Qi;ZHANG Yuan-gong;LI Jun-jie;YANG Geng-liang;Key Laboratory of Drug Quality Control of Hebei Province;College of Pharmaceutical Sciences;Hebei University;
MA Zheng-yue;YANG Qi;ZHANG Yuan-gong;LI Jun-jie;YANG Geng-liang;Key Laboratory of Drug Quality Control of Hebei Province;College of Pharmaceutical Sciences;Hebei University;
..............page:813-818
Pharmacophore identification of novel dual-target compounds targeting AChE and PARP-1
GUAN Xin-lei;JIANG Feng-chao;WANG Yue;WU Peng-fei;WANG Fang;CHEN Jian-guo;Department of Pharmacology;Huazhong University of Science and Technology;Department of Medicinal Chemistry;Huazhong University of Science and Technology;The Key Laboratory of Drug Target Researches and Pharmacodynamics Evaluation of Hubei Province;Huazhong University of Science and Technology;
GUAN Xin-lei;JIANG Feng-chao;WANG Yue;WU Peng-fei;WANG Fang;CHEN Jian-guo;Department of Pharmacology;Huazhong University of Science and Technology;Department of Medicinal Chemistry;Huazhong University of Science and Technology;The Key Laboratory of Drug Target Researches and Pharmacodynamics Evaluation of Hubei Province;Huazhong University of Science and Technology;
..............page:819-823
Advances in the pharmacological study of Morus alba L.
YANG Shuang;WANG Bao-lian;LI Yan;State Key Laboratory of Bioactive Substance and Function of Natural Medicines;Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
YANG Shuang;WANG Bao-lian;LI Yan;State Key Laboratory of Bioactive Substance and Function of Natural Medicines;Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:824-831
Research progress of hypoxia-inducible factor 1 inhibitors against tumors
NIU Fei;LI Yan;LAI Fang-fang;CHEN Xiao-guang;State Key Laboratory of Bioactive Substances of Functions of Natural Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
NIU Fei;LI Yan;LAI Fang-fang;CHEN Xiao-guang;State Key Laboratory of Bioactive Substances of Functions of Natural Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:832-836
Establishment of in vitro and cell-based drug screening model for Notch signaling pathway
NIU Qi;WU Fang;Shanghai Center for Systems Biomedicine;Shanghai Jiaotong University;
NIU Qi;WU Fang;Shanghai Center for Systems Biomedicine;Shanghai Jiaotong University;
..............page:837-842
Effect of beclin1 on vincristine-induced dopaminergic neurons injury in zebrafish
HU Zhan-ying;ZHANG Jing-pu;Institute of Medicinal Biotechnology;Chinese Academy of Medical Sciences and Peking Union Medical College;
HU Zhan-ying;ZHANG Jing-pu;Institute of Medicinal Biotechnology;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:843-848
Development of a novel screening assay for inhibitors targeting HIF-1α and P300 interaction
LAI Fang-fang;NIU Fei;YANG Han-ze;ZHOU Wan-qi;CHEN Xiao-guang;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
LAI Fang-fang;NIU Fei;YANG Han-ze;ZHOU Wan-qi;CHEN Xiao-guang;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:849-853
Application of temperature sensitive yeast models with definite target in the screening of potential human Pin1 inhibitors
ZHANG Jing;HAN Xiao-min;HU Wen-hui;GUO Zong-ru;HE Xiao-bo;SI Shu-yi;Institute of Medicinal Biotechnology;Chinese Academy of Medical Sciences and Peking Union Medical College;Key Lab of Food Safety Risk Assessment of Ministry of Health;China National Centre for Food Safety Risk Assessment;Guangzhou Institute of Biomedicine and Health;Chinese Academy of Sciences;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
ZHANG Jing;HAN Xiao-min;HU Wen-hui;GUO Zong-ru;HE Xiao-bo;SI Shu-yi;Institute of Medicinal Biotechnology;Chinese Academy of Medical Sciences and Peking Union Medical College;Key Lab of Food Safety Risk Assessment of Ministry of Health;China National Centre for Food Safety Risk Assessment;Guangzhou Institute of Biomedicine and Health;Chinese Academy of Sciences;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:854-860
Anti-tumor activity and mechanism of T03 in vitro and in vivo
TANG Ke;YANG Han-ze;LI Yan;TIAN Kang;LI Chao;ZHOU Wan-qi;NIU Fei;FENG Zhi-qiang;CHEN Xiao-guang;State Key Laboratory of Bioactive Substances and Functions of Nature Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
TANG Ke;YANG Han-ze;LI Yan;TIAN Kang;LI Chao;ZHOU Wan-qi;NIU Fei;FENG Zhi-qiang;CHEN Xiao-guang;State Key Laboratory of Bioactive Substances and Functions of Nature Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:861-868
Evaluation of the sedative and hypnotic effects of H1208
DONG Jing-wen;SHI Yuan;TANG Li-na;HU Wei;ZHANG Jian-jun;Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
DONG Jing-wen;SHI Yuan;TANG Li-na;HU Wei;ZHANG Jian-jun;Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:869-874
Effect and mechanism of total flavonoids of bugloss on rats with myocardial ischemia and reperfusion injury
XU Xiao-na;NIU Zi-ran;WANG Shou-bao;CHEN Yu-cai;GAO Li;FANG Lian-hua;DU Guan-hua;Beijing Key Laboratory of Drug Targets Identification and Drug Screening;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;China Key Laboratory of Traditional Uygur Medical Prescription;Xinjiang Uygur Autonomous Region Institute of Traditional Uygur Medicine;
XU Xiao-na;NIU Zi-ran;WANG Shou-bao;CHEN Yu-cai;GAO Li;FANG Lian-hua;DU Guan-hua;Beijing Key Laboratory of Drug Targets Identification and Drug Screening;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;China Key Laboratory of Traditional Uygur Medical Prescription;Xinjiang Uygur Autonomous Region Institute of Traditional Uygur Medicine;
..............page:875-881
The hepatic ChREBP expression and hyperinsulinemia in mice
HUANG Li-wei;YANG Xiao-meng;ZHANG Xiao-lin;WANG Li;YE Fei;Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
HUANG Li-wei;YANG Xiao-meng;ZHANG Xiao-lin;WANG Li;YE Fei;Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:882-887
Synthesis and biological evaluation of 2-(3-butynoicamidophenyl) benzothiazole derivatives as antitumor agents
YIN Gui-lin;LI Yan;TANG Ke;JIN Xiao-feng;CHEN Xiao-guang;LI Li;FENG Zhi-qiang;Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;Department of Pharmacology;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
YIN Gui-lin;LI Yan;TANG Ke;JIN Xiao-feng;CHEN Xiao-guang;LI Li;FENG Zhi-qiang;Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;Department of Pharmacology;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:888-895
Design, synthesis and biological evaluation of fingolimod analogues containing diphenyl ether moiety
LI Gang;HAN Wei-juan;JIN Jing;WANG Xiao-jian;XIAO Qiong;ZHOU Wan-qi;YIN Da-li;CHEN Xiao-guang;State Key Laboratory of Bioactive Substances and Function of Natural Medicine and Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
LI Gang;HAN Wei-juan;JIN Jing;WANG Xiao-jian;XIAO Qiong;ZHOU Wan-qi;YIN Da-li;CHEN Xiao-guang;State Key Laboratory of Bioactive Substances and Function of Natural Medicine and Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:896-904
A cyclotide against influenza A H1N1 virus from Viola yedoensis
LIU Min-zhi;YANG Yan;ZHANG Shu-xiang;TANG Liang;WANG Hui-min;CHEN Cheng-juan;SHEN Zhu-fang;CHENG Ke-di;KONG Jian-qiang;WANG Wei;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
LIU Min-zhi;YANG Yan;ZHANG Shu-xiang;TANG Liang;WANG Hui-min;CHEN Cheng-juan;SHEN Zhu-fang;CHENG Ke-di;KONG Jian-qiang;WANG Wei;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;
..............page:905-912
Meroterpenoids and isoberkedienolactone from endophytic fungus Penicillium sp. associated with Dysosma versipellis
LI Jun-wei;DUAN Rui-gang;ZOU Jian-hua;CHEN Ri-dao;CHEN Xiao-guang;DAI Jun-gui;State Key Laboratory of Bioactive Substance and Function of Natural Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;Institute of Pharmacy;Heilongjiang University of Chinese Medicine;
LI Jun-wei;DUAN Rui-gang;ZOU Jian-hua;CHEN Ri-dao;CHEN Xiao-guang;DAI Jun-gui;State Key Laboratory of Bioactive Substance and Function of Natural Medicines;Institute of Materia Medica;Chinese Academy of Medical Sciences and Peking Union Medical College;Institute of Pharmacy;Heilongjiang University of Chinese Medicine;
..............page:913-920
Pharmacokinetics of deflazacort tablets in healthy Chinese volunteers
DING Wen;DING Li;LI Wen-bo;PAN Hong;LIN Hong-da;Department of Pharmaceutical Analysis;China Pharmaceutical University;
DING Wen;DING Li;LI Wen-bo;PAN Hong;LIN Hong-da;Department of Pharmaceutical Analysis;China Pharmaceutical University;
..............page:921-926
Antitumor components screening of Stellera chamaejasme L. under the case of discrete distribution of active data
YANG Qian-xu;CHENG Meng-chun;WANG Li;KAN Xiao-xi;ZHU Xiao-xin;XIAO Hong-bin;CAS Key Laboratory of Separation Science for Analytical Chemistry;Dalian Institute of Chemical Physics;Chinese Academy of Sciences;Institute of Chinese Materia Medica Academy;China Academy of Chinese Medical Sciences;
YANG Qian-xu;CHENG Meng-chun;WANG Li;KAN Xiao-xi;ZHU Xiao-xin;XIAO Hong-bin;CAS Key Laboratory of Separation Science for Analytical Chemistry;Dalian Institute of Chemical Physics;Chinese Academy of Sciences;Institute of Chinese Materia Medica Academy;China Academy of Chinese Medical Sciences;
..............page:927-931
Two-dimensional zebrafish model combined with hyphenated chromatographic techniques for evaluation anti-osteoporosis activity of epimendin A and its metabolite baohuoside I
ZHAN Yang;WEI Ying-jie;SUN E;XU Feng-juan;JIA Xiao-bin;Key Laboratory of Oral Drug Delivery System of Chinese Materia Medica of State Administration of Traditional Chinese Medicine;Jiangsu Branch of China Academy of Chinese Medical Science;Department of Pharmaceutics;Jiangsu University;
ZHAN Yang;WEI Ying-jie;SUN E;XU Feng-juan;JIA Xiao-bin;Key Laboratory of Oral Drug Delivery System of Chinese Materia Medica of State Administration of Traditional Chinese Medicine;Jiangsu Branch of China Academy of Chinese Medical Science;Department of Pharmaceutics;Jiangsu University;
..............page:932-937
Plasma concentration and pharmacokinetics of ursolic acid carried in self-microemulsifying drug delivery system in rats studied by UPLC-MS/MS
CHEN Hai-xia;XU Xin-gang;HAN Yuan-yuan;LIU Jin;SHENG Li-song;SUN Dan-dan;ZHAO Xu-jie;YAN Xue-sheng;Qilu Hospital of Shandong University;Shandong Academy of Chinese Medicine;
CHEN Hai-xia;XU Xin-gang;HAN Yuan-yuan;LIU Jin;SHENG Li-song;SUN Dan-dan;ZHAO Xu-jie;YAN Xue-sheng;Qilu Hospital of Shandong University;Shandong Academy of Chinese Medicine;
..............page:938-941
Synthesis and permeation enhancement function of stabilized thiomer PAA-Cys-6MNA
YANG Jian-sheng;CHEN Xian-hui;ZHANG Hua;DAI Wen-bing;WANG Xue-qing;ZHANG Qiang;School of Pharmaceutical Sciences;Peking University;
YANG Jian-sheng;CHEN Xian-hui;ZHANG Hua;DAI Wen-bing;WANG Xue-qing;ZHANG Qiang;School of Pharmaceutical Sciences;Peking University;
..............page:942-948