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Acta Pharmacologica Sinica
1671-4083
2000 Issue 3
proceedings of symposium on the tenth anniversary of foundation of cjp/jcp club (10th cjp-99)
LEE Wen-Hsiumg; YANG Zao-Chen; WANG Yong-Ming;YAO Ming-Hui; CHICHIBU ShikoOrganized by Association of CJP/JCP Club Intl; Shanghai Medical University; Lanzhou Medical UniversitySupported by CCB Fund Intl
..............page:96-98
Volume- and calcium-activated chloride channels in human umbilical vein endothelial cells
ZHONG Ning; FANG Qi-Zhi; ZHANG Yi; ZHOU Zhao-Nian
..............page:25-30
Effect of Six flavonoids on proliferation of hepatic stellate cells in vitro
ZHANG Min; ZHANG Jun-Ping; JI Hai-Tao; WANG Jie-Song; QIAN Ding-Hua
..............page:63-66
Apoptosis induced by ceramide in hepatocellular carcinoma Bel7402 cells
ZHU Xiao-Feng; ZHANG Xiao-Shi; LI Zhi-Ming; YAO Yu-Qi; XE Bing-Fen; LIU Zong-Chao; ZFNG Yi-Xin
..............page:35-38
Effects of XW630 on cell proliferation, iNOS activity, and cGMP content in human osteoblast-like cell line TE85
SUN Lan; WENG Ling-Ling; ZHENG Hu; LIU Jing-Sheng
..............page:71-74
Nonhistone protein purified from porcine kidney acts as a suicide substrate inhibitor on furin-like enzyme
FEI Hao; LI Yan; WANG Li-Xiu; LUO Ming-Juan; LING Min-Hua; Cffl Cheng-Wu
..............page:75-80
Antidiabetic effect of Oenanthe javanica flavone
YANG Xin-Bo; HUANG Zheng-Ming; CAO Wen-Bin; ZHENG Ming; CHEN Hong-Yan; ZHANG Jing-Zhen
..............page:49-52
Urethane-induced hyperglycemia
WANG Min-Yan; REN Lei-Ming; DU Zhan-Jiang; FU Shao-Xuan
..............page:81-85
Panax notoginseng saponins attenuated cisplatin- induced nephrotoxicity
LIU Shi-Jie; ZHOU Shi-Wen
..............page:67-70
Molecular mechanism of apoptosis induced by ricin in HeLa cells
GAN Yong-Hua; PENG Shuang-Qing; LIU Hong-Ying
..............page:53-58
Effects of 2-[3-estrone-N-ethyl-piperazine-methyl]tetracycline (XW630) on osteoporosis in ovariectomized rats
SUN Lan; QIU Ming-Cai; WENG Ling-Ling; ZHENG Hu; LIU Jing-Sheng
..............page:10-14
Effects of dihydroartemisinin on fine structure of erythrocytic stages of Plasmodium berghei ANKA strain
CHEN Pei-Quan; YUAN Jie; DU Qiao-Yun; CHEN Lin; LI Guo-Qiao; HUANG Zhen- Yan; YANG Dong-Di; WU Ling-Ni
..............page:44-48
Antisense Ca~(2+) -calmodulin dependent protein kinase oligonu-cleotide inhibits bFGF-induced proliferation of rat vascular smooth muscle cells
HUANG Shao-Ling; DING Bo; LI Jiang; YU Qing-Sheng; GUO Zhao-Gui AIM: To investigate the role of Ca2 +-calmodulin dependent protein kinase on basic fibroblast growth factor -induced vascular smooth muscle cell proliferation and the inhibitory effect of antisense CCDPK oligonucleotides . METH-ODS: Before being exposed to bFGF; cultured rat VSMC CCDPK activity was inhibited by pretreatment with either a phosphorothioate-protected 17-mer antisense CCDPK ODN-directed against the initiation of translation sites of the p42 and p44 CCDPK isoform or with CCDPK kinase inhibitor PD98059. All ODN were introduced into cells by liposomal transfection. DNA synthesis was measured by [3H]thymidine incorporation. P44- and p42-CCDPK protein expression and phosphorylation were measured by Western blot. RESULTS: PD98059 inhibited bFGF-induced phosphorylation of CCDPK and DNA synthesis. Antisense CCDPK ODN 0.2-0.8 μmol·L-1 reduced both p44- and p42-CCDPK expression and phosphorylation of CCDPK in a concentration-dependent manner and DNA synthesis induced by bFGF. Lipofectin alone or sense and random CCDPK ODN did not affect p44- and p42-CCDPK protein expression or bFGF-induced phosphorylation of CCDPK or DNA synthesis. CONCLUSION: bFGF-stimulated rat VSMC proliferation is medi-ated by CCDPK. The antisense CCDPK ODN can inhibit bFGF-induced VSMC proliferation through down-regulating p44- and p42-CCDPK level.
..............page:39-43
Atypical antipsychotic effects of quetiapine fumarate in animal models
GUAN Han-Jun; DAI Jin; ZHU Xing-Zu
..............page:15-20
Biphasic manner of melittin on isolated guinea pig atria
YANG Shen; LIU Jun-E; ZHANG Ao-Zhen; JIANG Ming-Hua
..............page:31-34
Antisense oligodeoxynucleotide inhibits vascular endothelial growth factor in human glioma cells~1
ZHENG Shi-Xi; ZHOULi-Jun; ZHUXing-Zu; JIN You-Xin
..............page:21-24
Effect of forskolin on acetylcholine-induced current in rat pheochromocytoma cells
SHI Li-Jun; LIU Ling-Ai; WANG Chun-An
..............page:91-95